Influence of physical activity on postpartum weight retention among women, one year after childbirth / 中华流行病学杂志

Objective To explore the risk factors affecting the postpartum weight retention among women.Methods Six hundred eight postpartum women were involved to establish a baseline at 42 days of postpartum in Hefei Maternal and Child Health Center of Anhui province.Information regarding pre-pregnancy weight and weight gain during pregnancy and childbirth were obtained from the Maternal Information Management System.Results Women that under study were followed up at 3,6,9,and 12 months after childbirth,with 502,476,469 and 434 available copies of valid data,respectively.Indicators of physical activity were observed.Relationship between postpartum weight retention and physical activities were analyzed by mixed-effect model,together with repeated measure-analysis on related variances.The pre-pregnancy average weight of the study objects was (54.26 ± 8.11) kg,with postpartum average weight retention as (7.83 ± 5.12),(6.58 ± 5.21),(5.10 ± 5.19),(4.07 ±+ 4.96) and (3.43 ±+ 4.98) kg in 42 days,3,6,9,12 months,respectively.Rates of weight retention was significantly different at different times of repeated measures analysis on variance (P＜0.001).Physical activities were also significantly different at different time spans (P＜ 0.001).Results from the mixed-effects model showed that physical activity and postpartum weight retention were statistically associated when adjustments were made on factors as:pre-pregnancy BMI,ways of feeding,mode of delivery and other confounders (P＜0.001) while results from the mixed-effects model showed that these data were stable from step adjustment on confounding factors.Conclusion It seemed that the strength of physical activity play an important role on postpartum weight retention.

Prenatal diagnosis of a case with X-linked spondyloepiphyseal dysplasia tarda / 中华医学遗传学杂志

<p><b>OBJECTIVE</b>To analyze TRAPPC2 gene mutation in a family with X-linked spondyloepiphyseal dysplasia tarda and to provide genetic counseling and prenatal diagnosis.</p><p><b>METHODS</b>All of 4 exons of the TRAPPC2 gene and their flanking sequences in the proband and her father were analyzed with polymerase chain reaction and direct DNA sequencing. Genomic DNA of the probands' fetus was extracted from amniotic fluid sampled at 18th gestational week. Gender of the fetus was determined by the presence of SRY gene. The sequence of fetal TRAPPC2 gene was also analyzed.</p><p><b>RESULTS</b>A c.209G>A mutation was identified in exon 4 of the TRAPPC2 gene in the proband and her father. The fetus of was determined to be a male and also have carried the c.209G>A mutation.</p><p><b>CONCLUSION</b>A c.209G>A mutation of TRAPPC2 exon 4 probably underlies the clinical manifestations in this family. The proband is a carrier, and her fetus is a male carrying the same mutation. Prenatal diagnosis is an effective method for the prevention of the disease.</p>

Analysis on the risk factors of maternal weight for fetal macrosomia / 中华流行病学杂志

Objective To investigate the relationship between maternal weight gain and the increasing speed of weight in different pregnant terms and macrosomia.In order to reasonably manage pregnancy and decrease the morbidity of maerosomia.Methods 106 newborns whose birth weights were equal to or greater than 4000 g were specified as macrosomia,while 106 newborn with birth weights lying in 2500-3999 g were under the control group.A case-control study was conducted to compare the corresponding factors such as maternal BMI.weight before pregnancy and the change of weight during pregnancy respectively.Results Indicated by both simple and multiple unconditional logistic regression analysis,the cause of fetal macrosomia Was mainly associated with the factors including the maternal weight before pregnancy(OR=2.204,95％CI:1.377-3.529),matemal weight gain in 12-pregnant weeks(kgper week)(OR=1.961,95％CI:1.204-3.194),maternal weight gain in 20-gestation weeks(kg perweek)(OR=1.811,95％CI:1.078-3.041),maternal weight gain in 30-pregnant weeks(kg per week)(OR=1.858,95％CJ:1.095-3.153)and virile newborn(OR=2.630,95％CJ:1.420.4.850.When in 30-pregnant weeks.the pregnant women with 0.5-1.0 kg weight gain per week had 1.13 fold risks comparing to those whose weight gains were lexq than 0.5 kg per week.Conclusion Maternal weight before pregnancy,weight gain during pregnancy and fetal sex appeared a closer relation to macrosomia.It is necessary to monitor the change of maternal weight during different pregnancy periods,especially for the 30th-pregnant weeks.